We have established a cytogenetics and Molecular Genetics services in K S Hegde hospital. It is situated in K S Hegde Medical Acadamy (KSHEMA), NUCSER 3 floor. The centre is well equipped with advanced Flurescence microscope systems for perfoming high quality of cytogenetics and molecular genetics services.
Chromosomes are the thread like structures within the nucleus of each cell that contains DNA molecule (Genetic information). Any changes in the genetic makeup will cause direct or indirect adverse effects within the individuals.
Chromosomes are the vehicles of inheritance that reside in the cell nucleus. Clinical cytogenetics is the study of the relationship of chromosomal alterations (Translocation, Inversion, Duplication, Deletion, Ring Chromosome and Markers) and genetic diseases in human beings. Conventional Cytogenetics deals with the identification of the abnormalities through Karyotyping.
Indication of the patients will dictate what kind of sample to be procured & sent for testing to the Cytogenetics & Molecular Genetics Laboratory. Clinical indications varies from children to adults.
Molecular cytogenetics is the study of genetic disorders using new technologies that combine cytogenetic and molecular techniques. Fluorescence In Situ Hybridization (FISH) is a powerful technique for detecting chromosomal
changes in the cells and is one of the most frequently used techniques in the study of structural cytology of the cell nucleus. It provides a reliable means for studying the genetic composition of cells in mitosis as well as in interphase. The technique is highly sensitive where individual genes can be detected and has high multiplicity of several probes can be used on target nucleus.
Prenatal Diagnosis of Anueploidies by FISH:
Postnatal Diagnosis: Detection of Microdeletion Syndromes. Eg- DiGeorge syndrome, Prader – Willi/Angelman Syndrome, William’s syndrome.
Preimplantation Genetic diagnosis (PGD): Involving interphase FISH can decrease the risk to transfer an affected embryo eg: trisomy 21 or X-linked disease eg: DMD, Haemophilia etc.
Cancer Genetics : Used for diagnosis, prognosis and follow-up of Hematologic malignancies.
Dr. Prashanth Shetty PhD
Coordinator – Genetics Laboratory
Ph – 2204491 Extn – 249
Mobile – 9448348007
E-mail – email@example.com